Urolithin A is one of the most talked-about longevity ingredients right now, promising support for cellular energy, muscle strength, and healthy aging. But the label is where it gets slippery, because two products can both say "urolithin A" and deliver very different amounts of the compound that does the work. We analyzed thousands of verified buyer reviews, recent sales data, and expert evaluations to find six urolithin A supplements that state what they contain and back it up.
Every product we compared, in ranked order. Tap through to Amazon to check today's price, or jump to the full review below.
1
Timeline Mitopure Softgels
Best Overall
Timeline Mitopure Urolithin A Softgels
4.9
Mitopure urolithin A · Softgel · 30 servings
Our top-graded urolithin A supplement: Timeline's original Mitopure softgel, the format most directly tied to the brand's published clinical research on muscle strength and cellular renewal.
The easiest way to take Timeline's clinically studied Mitopure urolithin A: a strawberry-flavored daily gummy with the same active ingredient behind the brand's muscle-strength and healthy-aging research.
A liposomal NAD+ formula that folds urolithin A in alongside resveratrol, CoQ10, muira puama and giloy, aimed at buyers who want a broader cellular-energy stack rather than urolithin A alone.
Not a urolithin A source - a freeze-dried, grass-fed desiccated beef liver supplement often stacked alongside mitochondrial-support ingredients for broader energy and nutrient density.
Etta Vita Urolithin-A Complex with Shilajit & Tongkat Ali
4.4
Urolithin A + shilajit blend · Capsule · 30 servings
The best-value formula in this lineup, pairing urolithin A with shilajit, organic sea moss, ashwagandha and tongkat ali in a single vegan capsule aimed at energy, hormone balance and focus.
Understand the category before you buy - what the science actually says, and which specs matter.
Every bottle in this space leans on the same longevity language, yet the formulas range from a single pure dose to sprawling blends with a dozen other ingredients. Here is how urolithin A works in your body, why the milligram number on the label matters more than almost anything else, and the features worth comparing before you buy.
What does a urolithin A supplement actually do?
Urolithin A is a postbiotic, a compound your gut bacteria are supposed to produce after you eat pomegranates and certain nuts. Once it reaches your cells, research links it to a process called mitophagy, which is your body clearing out worn-out mitochondria so healthier ones can take over. That is why these supplements are marketed around cellular energy, muscle function, and healthy aging.
The catch is what happens before any of that. Here is the short version:
You eat pomegranate or walnuts, which contain the raw precursors.
Your gut bacteria are meant to convert those precursors into urolithin A.
Only then does your body get the active compound.
A supplement skips the first two steps and hands your cells the finished ingredient directly.
Why the milligram number matters more than the fruit on the label
This is the part most shoppers miss. Studies suggest a large share of people simply do not carry the gut bacteria needed to make meaningful urolithin A from food, so eating more pomegranate does very little for them. That is the whole case for supplementing: a direct dose is far more reliable than hoping your microbiome cooperates.
Which makes the actual milligrams of urolithin A per serving the single most important spec. The studied amount sits around 500 mg, and honest products state that number plainly. In this lineup, the Timeline Mitopure Powder sachet spells out 500 mg per sachet taken once a day, and the branded Mitopure softgels and gummies (2 per day) are built around the same standardized ingredient. The blends behave differently. The Etta Vita Liposomal NAD+ formula and the Etta Vita Urolithin-A Complex fold urolithin A in alongside ingredients like resveratrol, CoQ10, shilajit, sea moss, ashwagandha, and tongkat ali, which can be appealing if you want more than one benefit in a single capsule, but you should read closely for a stated urolithin A figure. A product that only advertises "pomegranate extract" with no urolithin A number may deliver very little of the compound you are actually paying for. When the number is missing, third-party testing is your next best signal that what is on the label is in the capsule.
Which specs actually matter?
Once you understand the ingredient, a handful of details decide which product fits you:
Stated urolithin A dose: Look for a clear milligram figure, ideally near the studied 500 mg. The Mitopure Powder states 500 mg per sachet; a vague "pomegranate blend" with no number is the red flag.
Branded vs generic urolithin A: The Timeline products use Mitopure, a standardized, clinically studied form, so you know what you are getting. Generic listings vary more, which is where testing matters most.
Third-party testing: Both Etta Vita products are third-party tested and made in the USA, an important check when a formula does not print an exact dose.
Single ingredient vs blend: The Mitopure line is essentially pure urolithin A. The Etta Vita formulas add NAD+ support or adaptogens, useful if you want a stack rather than one compound.
Form and daily routine: This lineup spans softgels, strawberry gummies, a berry powder sachet, and capsules. Serving effort ranges from 1 sachet a day up to 6 capsules a day, so pick what you will actually keep taking.
Dietary fit: Both Etta Vita products are vegan, gluten-free, and keto-friendly, while the Ancestral Supplements option is a grass-fed beef liver capsule with no urolithin A, included for people comparing broader cellular-energy supports.
How we grade products
Graded Picks rankings are aggregated from several independent signals: verified buyer ratings and the size of the review base for credibility, recent monthly purchase volume for relevance, assessments from trusted health and longevity publications, and how each product places in leading category lineups. For urolithin A supplements we weigh:
Clarity and size of the stated urolithin A dose
Use of a standardized, studied ingredient
Third-party testing and manufacturing standards
Single-ingredient purity vs blend value
Form, flavor, and daily serving effort
Dietary compliance and clean formulation
Overall value for the price
Health note: Urolithin A is a relatively new supplement ingredient, and long-term research is still building. Talk to a healthcare provider before starting it, especially if you are pregnant, nursing, or taking any medication, and treat it as support alongside exercise and a balanced diet, not a substitute for them.
In-Depth Reviews
Everything we learned from buyer reviews and expert testing, product by product.
Timeline Mitopure Softgels
Best Overall
1. Timeline Mitopure Urolithin A Softgels
4.9
The Mitopure softgel is Timeline's flagship format and the one most closely tied to its clinical trial program - placebo-controlled human studies on a 500mg daily dose of this ingredient have reported measurable gains in muscle strength and mitochondrial renewal markers over 16 weeks, with no serious adverse reactions reported across the published research. Unflavored and taken as two softgels a day, it's a straightforward single-ingredient product for buyers who want to dose urolithin A predictably rather than as part of a larger blend. Independent supplement reviewers describe Mitopure as the most heavily researched urolithin A brand on the market, with dozens of human trials behind the ingredient. The tradeoff versus the gummy version is simply personal preference around swallowing a softgel daily.
Primary active ingredientMitopure urolithin A
FormSoftgel
Servings per container30 (60 softgels)
Serving dose2 softgels per day
FlavorUnflavored
Dietary complianceManufactured under GMP standards
ManufacturerTimeline
Pros
The most heavily clinically researched urolithin A ingredient on the market
Single-ingredient formula makes dosing straightforward and predictable
Unflavored softgel with no added sugar
Simple two-a-day dosing schedule
Backed by multiple placebo-controlled human trials on muscle strength and mitochondrial renewal
Cons
Requires swallowing a softgel rather than chewing a gummy
Single-ingredient formula won't appeal to buyers wanting an all-in-one blend
Benefits build gradually over weeks to months, not immediately
Who is it for?
Buyers who want the most clinically documented urolithin A format and don't mind a daily softgel.
Who is it not for?
Anyone who strongly prefers a chewable format or wants additional ingredients like adaptogens bundled in.
Timeline built Mitopure as a highly purified, standardized form of urolithin A, and the gummy format exists to remove the last barrier to actually taking it every day - no pills, no mixing, just two gummies with breakfast. The active ingredient is the same Mitopure urolithin A used across Timeline's clinical research program, which has reported improved muscle strength and mitochondrial renewal markers in placebo-controlled human trials at a 500mg daily dose. Buyers consistently describe the strawberry flavor as pleasant enough to stick with long-term, which matters for a supplement whose benefits build over months rather than days. As with any gummy supplement, expect a small amount of added sugar per serving compared to the softgel version of this same ingredient.
Primary active ingredientMitopure urolithin A
FormGummy
Servings per container30 (60 gummies)
Serving dose2 gummies per day
FlavorStrawberry
Dietary complianceManufactured under GMP standards
ManufacturerTimeline
Pros
Uses the same clinically studied Mitopure urolithin A as Timeline's capsule products
Easy daily gummy format with no pills to swallow
Pleasant strawberry flavor that's easy to stick with long-term
Backed by Timeline's published mitochondrial and muscle-strength research
Simple two-a-day dosing schedule
Cons
Contains added sugar and gummy binders that the softgel version avoids
Benefits build gradually over weeks to months, not immediately
Priced the same as the softgel version despite the added excipients
Who is it for?
Anyone who dislikes swallowing pills and wants the easiest possible way to take a daily urolithin A dose.
Who is it not for?
Buyers who want to avoid added sugar entirely or who prefer a more concentrated capsule format.
3. Etta Vita Liposomal NAD+ Supplement with Urolithin A
4.5
This Etta Vita formula centers on NAD+ support (using liposomal delivery for better absorption) and layers in urolithin A, resveratrol, CoQ10 and giloy extract as complementary actives, all in an extended-release capsule taken twice daily. It's built for buyers thinking about cellular energy production more broadly - NAD+ and mitophagy pathways are related but distinct mechanisms - rather than isolating urolithin A's specific muscle and mitochondrial benefits. The brand states the product is made in the USA with third-party testing, and a discount at the time of our scan makes it one of the more affordable multi-ingredient options here. As with the brand's other blend product, exact per-ingredient dosing isn't broken out on the label, so buyers wanting a precise urolithin A number should look at the single-ingredient Timeline options instead.
Primary active ingredientNAD+ (nicotinamide) + urolithin A, resveratrol, CoQ10 & giloy blend
FormExtended-release capsule
Servings per container30 (60 capsules)
Serving dose2 capsules per day
FlavorUnflavored
Dietary complianceVegan, vegetarian, gluten-free, keto, made in USA, 3rd-party tested
ManufacturerEtta Vita
Pros
Liposomal delivery is designed to improve absorption versus standard NAD+ capsules
Combines urolithin A with resveratrol and CoQ10 for a broader cellular-energy stack
Extended-release format spreads absorption out over the day
Vegan and allergen-free formulation
Discounted pricing at the time of our scan
Cons
Proprietary blend means the exact urolithin A dose isn't broken out on the label
NAD+ and urolithin A work through different mechanisms, so effects can be harder to attribute
Less independent research on this specific multi-ingredient combination than on standalone urolithin A
Who is it for?
Buyers who want a combined NAD+ and urolithin A cellular-energy stack rather than a single-ingredient approach.
Who is it not for?
Anyone who wants to isolate and track urolithin A's studied effects specifically.
This is Timeline's powder format of Mitopure, delivering the same standardized 500mg urolithin A dose used in the brand's clinical trials, packaged as single-serving berry-flavored sachets you mix into water or a smoothie. It suits buyers who prefer not to swallow pills at all and don't mind an extra mixing step each morning. Buyer feedback on this specific format runs more mixed than the capsule and gummy versions, with some noting the berry flavor and texture take getting used to when dissolved compared to other powdered supplements. If you already know you get on well with Mitopure in another format, the powder is a reasonable way to switch things up; first-time buyers may want to start with the softgel or gummy version instead.
Primary active ingredientMitopure urolithin A
FormPowder sachet
Servings per container30 sachets
Serving dose500mg per sachet, 1 per day
FlavorBerry
Dietary complianceManufactured under GMP standards
ManufacturerTimeline
Pros
Same clinically dosed 500mg Mitopure urolithin A used in the brand's published research
No pills to swallow - mixes into water or a smoothie
Single-sachet daily dosing is simple to track
Berry flavor works well blended into a smoothie
Cons
Texture and flavor take some getting used to when mixed with just water
Requires a mixing step each day, unlike the grab-and-go gummy or softgel formats
Feedback on this specific format has been more mixed than the capsule and gummy versions
Who is it for?
Existing Mitopure users who want a mixable powder alternative to the capsule or gummy formats.
Who is it not for?
First-time urolithin A buyers, who are better served starting with the softgel or gummy version.
Worth flagging up front: this product doesn't contain urolithin A. It's a whole-food desiccated organ supplement made from grass-fed, pasture-raised beef liver, included here because buyers researching mitochondrial and energy-support supplements frequently stack it alongside urolithin A products rather than choosing between them. The liver is freeze-dried to preserve heat-sensitive nutrients like vitamin A, B12, folate and iron, with no synthetic fillers in the capsule. Buyers report noticing more steady energy and better overall nutrient status after a couple of months of consistent use, though that's a broad whole-food nutrition effect rather than the targeted mitophagy mechanism urolithin A is studied for. If you're specifically shopping for urolithin A, treat this as an optional add-on rather than a substitute.
Primary active ingredientGrass-fed desiccated beef liver (no urolithin A)
FormCapsule
Servings per container30 (180 capsules)
Serving dose6 capsules per day
Key nutrientsVitamin A, B12, folate, iron, copper, zinc
Dietary complianceNon-GMO, freeze-dried, no synthetic fillers
ManufacturerAncestral Supplements
Pros
Whole-food nutrient density (vitamin A, B12, iron, folate) from grass-fed liver
6. Etta Vita Urolithin-A Complex with Shilajit & Tongkat Ali
4.4
Etta Vita's Complex takes a different approach than the single-ingredient Timeline products: it stacks urolithin A alongside shilajit, organic sea moss, ashwagandha, tongkat ali and muira puama into one vegan, allergen-free capsule marketed for energy, libido and hormone balance in addition to cellular health. The brand states the formula is made in the USA and third-party tested, and it's priced well below the single-ingredient options in this category, which makes it the easiest entry point for buyers who want to try urolithin A alongside well-known adaptogens rather than on its own. Because it's a proprietary blend, buyers who want to dose urolithin A at a specific, isolated amount should compare label details closely against the single-ingredient options before choosing this one.
Primary active ingredientUrolithin A + shilajit, sea moss, ashwagandha & tongkat ali blend
FormCapsule
Servings per container30 (90 capsules)
Serving dose3 capsules per day
FlavorShilajit & sea moss
Dietary complianceVegan, gluten-free, keto, paleo, made in USA, 3rd-party tested
ManufacturerEtta Vita
Pros
Lowest price per bottle of any product in this lineup
Combines urolithin A with well-studied adaptogens (ashwagandha, shilajit, tongkat ali) in one capsule
Vegan, allergen-free formula suitable for most diets
Made in the USA with stated third-party testing
Broader focus (energy, hormone balance, focus) beyond mitochondrial support alone
Cons
Proprietary blend format makes it hard to know the exact urolithin A dose per serving
Multiple active ingredients make it harder to isolate what's driving any given effect
Less independent clinical research behind this specific combination than single-ingredient Mitopure products
Who is it for?
Budget-conscious buyers who want urolithin A bundled with popular adaptogens rather than as a standalone ingredient.
Who is it not for?
Anyone who wants to precisely track a clinically studied urolithin A dose on its own.
The stars you see are the Graded Picks cumulative score, not a single retailer's average. It blends verified buyer reviews aggregated across major retailers, assessments from professional reviewers and expert testers, and how prominently the product features in leading category lineups.
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